If you intend to use the Quick Access Toolbar a lot, have a look at the new things you can do - such as sorting the icons...
Put your most used shortcuts to the far right of the QAT - this is closer to the centre of the drawing window.
As with 2010, you can move the QAT below the Ribbon if you like.
I fear the day that the Revit UI adopts a tool like the CUI manager from AutoCAD. Keep it simple!